Mitogen-activated protein kinase kinase kinase 10

BE0009462ProteinHumansMAP3K10

Activates the JUN N-terminal pathway. It is acted on by 2 drugs in DrugBank.

Gene name
MAP3K10
UniProtKB entry
Q02779Swiss-Prot
Residues / weight
954 residues · 103,693 Da
Also known as
2.7.11.25 · Mixed lineage kinase 2 · MLK2 · MST · Protein kinase MST

Resolves to

Protein
UniProtQ02779UniProt nameM3K10_HUMAN
Gene
HGNCHGNC:6849NCBI Gene4294GeneCardsMAP3K10
Pharmacology
IUPHAR/GtoPdb2070KEGGhsa:4294
Structure
PDB2RF0
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 10, how selective are they, and which programs against it are still in active trials?

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