Mitogen-activated protein kinase kinase kinase 11

BE0009463ProteinHumansMAP3K11

Activates the JUN N-terminal pathway. It is acted on by 2 drugs in DrugBank.

Gene name
MAP3K11
UniProtKB entry
Q16584Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
847 residues · 92,687 Da
Also known as
2.7.11.25 · Mixed lineage kinase 3 · MLK3 · PTK1 · SPRK

Resolves to

Protein
UniProtQ16584UniProt nameM3K11_HUMAN
Gene
HGNCHGNC:6850NCBI Gene4296GeneCardsMAP3K11
Pharmacology
IUPHAR/GtoPdb2071KEGGhsa:4296
Structure
PDB5K26PDB5K28PDB6AQB
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 11, how selective are they, and which programs against it are still in active trials?

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