Mitogen-activated protein kinase kinase kinase 13

BE0009465ProteinHumansMAP3K13

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. It is acted on by 2 drugs in DrugBank.

Gene name
MAP3K13
UniProtKB entry
O43283Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
966 residues · 108,295 Da
Also known as
2.7.11.25 · Leucine zipper-bearing kinase · LZK · Mixed lineage kinase · MLK

Resolves to

Protein
UniProtO43283UniProt nameM3K13_HUMAN
Gene
HGNCHGNC:6852NCBI Gene9175GeneCardsMAP3K13
Pharmacology
IUPHAR/GtoPdb2073KEGGhsa:9175
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 13, how selective are they, and which programs against it are still in active trials?

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