Mitogen-activated protein kinase kinase kinase 15

BE0009466ProteinHumansMAP3K15

Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). It is acted on by 1 drug in DrugBank.

Gene name
MAP3K15
UniProtKB entry
Q6ZN16Swiss-Prot
Residues / weight
1,313 residues · 147,436 Da
Also known as
2.7.11.25 · Apoptosis signal-regulating kinase 3 · ASK3 · MAPK/ERK kinase kinase 15 · MEK kinase 15

Resolves to

Protein
UniProtQ6ZN16UniProt nameM3K15_HUMAN
Gene
HGNCHGNC:31689NCBI Gene389840GeneCardsMAP3K15
Pharmacology
KEGGhsa:389840
Structure
PDB6V0M
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 15, how selective are they, and which programs against it are still in active trials?

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