Mitogen-activated protein kinase kinase kinase 3

BE0009467ProteinHumansMAP3K3

Component of a protein kinase signal transduction cascade. It is acted on by 1 drug in DrugBank.

Gene name
MAP3K3
UniProtKB entry
Q99759Swiss-Prot
Residues / weight
626 residues · 70,897 Da
Also known as
2.7.11.25 · MAPK/ERK kinase kinase 3 · MAPKKK3 · MEK kinase 3 · MEKK 3

Resolves to

Protein
UniProtQ99759UniProt nameM3K3_HUMAN
Gene
HGNCHGNC:6855NCBI Gene4215GeneCardsMAP3K3
Pharmacology
KEGGhsa:4215
Structure
PDB2C60PDB2JRHPDB2O2V
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 3, how selective are they, and which programs against it are still in active trials?

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