Mitogen-activated protein kinase kinase kinase 4

BE0009468ProteinHumansMAP3K4

Component of a protein kinase signal transduction cascade. It is acted on by 1 drug in DrugBank.

Gene name
MAP3K4
UniProtKB entry
Q9Y6R4Swiss-Prot
Cellular location
Cytoplasm, perinuclear region
Residues / weight
1,608 residues · 181,683 Da
Also known as
2.7.11.25 · KIAA0213 · MAP three kinase 1 · MAPK/ERK kinase kinase 4 · MAPKKK4

Resolves to

Protein
UniProtQ9Y6R4UniProt nameM3K4_HUMAN
Gene
HGNCHGNC:6856NCBI Gene4216GeneCardsMAP3K4
Pharmacology
KEGGhsa:4216
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 4, how selective are they, and which programs against it are still in active trials?

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