Mitogen-activated protein kinase kinase kinase 6

BE0009469ProteinHumansMAP3K6

Component of a protein kinase signal transduction cascade. It is acted on by 1 drug in DrugBank.

Gene name
MAP3K6
UniProtKB entry
O95382Swiss-Prot
Residues / weight
1,288 residues · 142,595 Da
Also known as
2.7.11.25 · Apoptosis signal-regulating kinase 2 · ASK2 · MAPKKK6 · MEKK6

Resolves to

Protein
UniProtO95382UniProt nameM3K6_HUMAN
Gene
HGNCHGNC:6858NCBI Gene9064GeneCardsMAP3K6
Pharmacology
IUPHAR/GtoPdb2081KEGGhsa:9064
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 6, how selective are they, and which programs against it are still in active trials?

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