Mitogen-activated protein kinase kinase kinase kinase 1

BE0009470ProteinHumansMAP4K1

Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). It is acted on by 1 drug in DrugBank.

Gene name
MAP4K1
UniProtKB entry
Q92918Swiss-Prot
Residues / weight
833 residues · 91,296 Da
Also known as
2.7.11.1 · Hematopoietic progenitor kinase · HPK1 · MAPK/ERK kinase kinase kinase 1 · MEK kinase kinase 1

Resolves to

Protein
UniProtQ92918UniProt nameM4K1_HUMAN
Gene
HGNCHGNC:6863NCBI Gene11184GeneCardsMAP4K1
Pharmacology
IUPHAR/GtoPdb2085KEGGhsa:11184
Structure
PDB6CQDPDB6CQEPDB6CQF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase kinase 1, how selective are they, and which programs against it are still in active trials?

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