Mitogen-activated protein kinase kinase kinase kinase 2

BE0009471ProteinHumansMAP4K2

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 1 drug in DrugBank.

Gene name
MAP4K2
UniProtKB entry
Q12851Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
820 residues · 91,555 Da
Also known as
2.7.11.1 · B lymphocyte serine/threonine-protein kinase · GC kinase · GCK · Germinal center kinase

Resolves to

Protein
UniProtQ12851UniProt nameM4K2_HUMAN
Gene
HGNCHGNC:6864NCBI Gene5871GeneCardsMAP4K2
Pharmacology
IUPHAR/GtoPdb2086KEGGhsa:5871
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase kinase 2, how selective are they, and which programs against it are still in active trials?

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