Mitogen-activated protein kinase kinase kinase kinase 3

BE0009472ProteinHumansMAP4K3

Serine/threonine kinase that plays a role in the response to environmental stress. It is acted on by 1 drug in DrugBank.

Gene name
MAP4K3
UniProtKB entry
Q8IVH8Swiss-Prot
Residues / weight
894 residues · 101,315 Da
Also known as
2.7.11.1 · Germinal center kinase-related protein kinase · GLK · MAPK/ERK kinase kinase kinase 3 · MEK kinase kinase 3

Resolves to

Protein
UniProtQ8IVH8UniProt nameM4K3_HUMAN
Gene
HGNCHGNC:6865NCBI Gene8491GeneCardsMAP4K3
Pharmacology
IUPHAR/GtoPdb2087KEGGhsa:8491
Structure
PDB5J5T
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase kinase 3, how selective are they, and which programs against it are still in active trials?

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