Mitogen-activated protein kinase kinase kinase kinase 4

BE0009473ProteinHumansMAP4K4

Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. It is acted on by 1 drug in DrugBank.

Gene name
MAP4K4
UniProtKB entry
O95819Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,239 residues · 142,100 Da
Also known as
2.7.11.1 · HGK · HPK/GCK-like kinase HGK · KIAA0687 · MAPK/ERK kinase kinase kinase 4

Resolves to

Protein
UniProtO95819UniProt nameM4K4_HUMAN
Gene
HGNCHGNC:6866NCBI Gene9448GeneCardsMAP4K4
Pharmacology
IUPHAR/GtoPdb2088KEGGhsa:9448
Structure
PDB4OBOPDB4OBPPDB4OBQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase kinase 4, how selective are they, and which programs against it are still in active trials?

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