Mitogen-activated protein kinase kinase kinase kinase 5

BE0009474ProteinHumansMAP4K5

May play a role in the response to environmental stress. It is acted on by 1 drug in DrugBank.

Gene name
MAP4K5
UniProtKB entry
Q9Y4K4Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
846 residues · 95,053 Da
Also known as
2.7.11.1 · KHS · Kinase homologous to SPS1/STE20 · MAPK/ERK kinase kinase kinase 5 · MEK kinase kinase 5

Resolves to

Protein
UniProtQ9Y4K4UniProt nameM4K5_HUMAN
Gene
HGNCHGNC:6867NCBI Gene11183GeneCardsMAP4K5
Pharmacology
IUPHAR/GtoPdb2089KEGGhsa:11183
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase kinase 5, how selective are they, and which programs against it are still in active trials?

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