Mitogen-activated protein kinase 15

BE0009475ProteinHumansMAPK15

Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). It is acted on by 1 drug in DrugBank.

Gene name
MAPK15
UniProtKB entry
Q8TD08Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, cilium basal body
Residues / weight
544 residues · 59,832 Da
Also known as
2.7.11.24 · ERK-7 · ERK-8 · ERK7 · ERK8

Resolves to

Protein
UniProtQ8TD08UniProt nameMK15_HUMAN
Gene
HGNCHGNC:24667NCBI Gene225689GeneCardsMAPK15
Pharmacology
IUPHAR/GtoPdb2090KEGGhsa:225689
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
7+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Mitogen-activated protein kinase 15, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In