Macrophage-stimulating protein receptor

BE0009490ProteinHumansMST1R

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. It is acted on by 5 drugs in DrugBank.

Gene name
MST1R
UniProtKB entry
Q04912Swiss-Prot
Cellular location
Membrane
Residues / weight
1,400 residues · 152,240 Da
Also known as
2.7.10.1 · CDw136 · MSP receptor · p185-Ron · Protein-tyrosine kinase 8

Resolves to

Protein
UniProtQ04912UniProt nameRON_HUMAN
Gene
HGNCHGNC:7381NCBI Gene4486GeneCardsMST1R
Pharmacology
IUPHAR/GtoPdb1816KEGGhsa:4486
Structure
PDB3PLSPDB4FWWPDB4QT8
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Macrophage-stimulating protein receptor, how selective are they, and which programs against it are still in active trials?

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