Muscle, skeletal receptor tyrosine-protein kinase

BE0009491ProteinHumansMUSK

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). It is acted on by 2 drugs in DrugBank.

Gene name
MUSK
UniProtKB entry
O15146Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
869 residues · 97,055 Da
Also known as
2.7.10.1 · Muscle-specific kinase receptor · Muscle-specific tyrosine-protein kinase receptor · MuSK

Resolves to

Protein
UniProtO15146UniProt nameMUSK_HUMAN
Gene
HGNCHGNC:7525NCBI Gene4593GeneCardsMUSK
Pharmacology
IUPHAR/GtoPdb1847KEGGhsa:4593
Structure
PDB8S9PPDB9LGGPDB9NWG
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscle, skeletal receptor tyrosine-protein kinase, how selective are they, and which programs against it are still in active trials?

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