NUAK family SNF1-like kinase 1

BE0009502ProteinHumansNUAK1

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. It is acted on by 2 drugs in DrugBank.

Gene name
NUAK1
UniProtKB entry
O60285Swiss-Prot
Cellular location
Nucleus
Residues / weight
661 residues · 74,304 Da
Also known as
2.7.11.1 · AMPK-related protein kinase 5 · ARK5 · KIAA0537 · Omphalocele kinase 1

Resolves to

Protein
UniProtO60285UniProt nameNUAK1_HUMAN
Gene
HGNCHGNC:14311NCBI Gene9891GeneCardsNUAK1
Pharmacology
IUPHAR/GtoPdb2129KEGGhsa:9891
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NUAK family SNF1-like kinase 1, how selective are they, and which programs against it are still in active trials?

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