Serine/threonine-protein kinase OSR1

BE0009504ProteinHumansOXSR1

Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). It is acted on by 2 drugs in DrugBank.

Gene name
OXSR1
UniProtKB entry
O95747Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
527 residues · 58,022 Da
Also known as
2.7.11.1 · KIAA1101 · OSR1 · Oxidative stress-responsive 1 protein

Resolves to

Protein
UniProtO95747UniProt nameOXSR1_HUMAN
Gene
HGNCHGNC:8508NCBI Gene9943GeneCardsOXSR1
Pharmacology
KEGGhsa:9943
Structure
PDB2V3SPDB2VWIPDB3DAK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase OSR1, how selective are they, and which programs against it are still in active trials?

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