Phosphatidylinositol 4-kinase beta

BE0009513ProteinHumansPI4KB

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It is acted on by 4 drugs in DrugBank.

Gene name
PI4KB
UniProtKB entry
Q9UBF8Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
816 residues · 91,378 Da
Also known as
2.7.1.67 · NPIK · PI4K-beta · PI4K92 · PI4Kbeta

Resolves to

Protein
UniProtQ9UBF8UniProt namePI4KB_HUMAN
Gene
HGNCHGNC:8984NCBI Gene5298GeneCardsPI4KB
Pharmacology
IUPHAR/GtoPdb2149KEGGhsa:5298
Structure
PDB2N73PDB4D0LPDB4D0M
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 4-kinase beta, how selective are they, and which programs against it are still in active trials?

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