Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

BE0009517ProteinHumansPIP4K2B

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). It is acted on by 1 drug in DrugBank.

Gene name
PIP4K2B
UniProtKB entry
P78356Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
416 residues · 47,378 Da
Also known as
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta · 2.7.1.149 · Diphosphoinositide kinase 2-beta · Phosphatidylinositol 5-phosphate 4-kinase type II beta · PI(5)P 4-kinase type II beta

Resolves to

Protein
UniProtP78356UniProt namePI42B_HUMAN
Gene
HGNCHGNC:8998NCBI Gene8396GeneCardsPIP4K2B
Pharmacology
KEGGhsa:8396
Structure
PDB1BO1PDB3WZZPDB3X01
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, how selective are they, and which programs against it are still in active trials?

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