Serine/threonine-protein kinase N1

BE0009520ProteinHumansPKN1

PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. It is acted on by 2 drugs in DrugBank.

Gene name
PKN1
UniProtKB entry
Q16512Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
942 residues · 103,931 Da
Also known as
2.7.11.13 · PAK-1 · PAK1 · PKN · PRK1

Resolves to

Protein
UniProtQ16512UniProt namePKN1_HUMAN
Gene
HGNCHGNC:9405NCBI Gene5585GeneCardsPKN1
Pharmacology
IUPHAR/GtoPdb1520KEGGhsa:5585
Structure
PDB1CXZPDB1URFPDB2RMK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase N1, how selective are they, and which programs against it are still in active trials?

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