Serine/threonine-protein kinase PLK4

BE0009524ProteinHumansPLK4

Serine/threonine-protein kinase that plays a central role in centriole duplication. It is acted on by 2 drugs in DrugBank.

Gene name
PLK4
UniProtKB entry
O00444Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Residues / weight
970 residues · 108,971 Da
Also known as
2.7.11.21 · PLK-4 · Polo-like kinase 4 · SAK · Serine/threonine-protein kinase 18

Resolves to

Protein
UniProtO00444UniProt namePLK4_HUMAN
Gene
HGNCHGNC:11397NCBI Gene10733GeneCardsPLK4
Pharmacology
IUPHAR/GtoPdb2171KEGGhsa:10733
Structure
PDB2N19PDB3COKPDB4JXF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PLK4, how selective are they, and which programs against it are still in active trials?

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