Receptor-interacting serine/threonine-protein kinase 1

BE0009531ProteinHumansRIPK1

Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). It is acted on by 6 drugs in DrugBank.

Gene name
RIPK1
UniProtKB entry
Q13546Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
671 residues · 75,930 Da
Also known as
2.7.11.1 · Cell death protein RIP · Receptor-interacting protein 1 · RIP · RIP-1

Resolves to

Protein
UniProtQ13546UniProt nameRIPK1_HUMAN
Gene
HGNCHGNC:10019NCBI Gene8737GeneCardsRIPK1
Pharmacology
IUPHAR/GtoPdb2189KEGGhsa:8737
Structure
PDB24IBPDB24ICPDB4ITH
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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38GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor-interacting serine/threonine-protein kinase 1, how selective are they, and which programs against it are still in active trials?

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