Receptor-interacting serine/threonine-protein kinase 2

BE0009532ProteinHumansRIPK2

Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). It is acted on by 2 drugs in DrugBank.

Gene name
RIPK2
UniProtKB entry
O43353Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
540 residues · 61,194 Da
Also known as
2.7.11.1 · CARD-containing IL-1 beta ICE-kinase · CARD-containing interleukin-1 beta-converting enzyme-associated kinase · CARDIAK · Receptor-interacting protein 2

Resolves to

Protein
UniProtO43353UniProt nameRIPK2_HUMAN
Gene
HGNCHGNC:10020NCBI Gene8767GeneCardsRIPK2
Pharmacology
IUPHAR/GtoPdb2190KEGGhsa:8767
Structure
PDB2N7ZPDB2N83PDB4C8B
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor-interacting serine/threonine-protein kinase 2, how selective are they, and which programs against it are still in active trials?

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