Serine/threonine-protein kinase SIK2

BE0009538ProteinHumansSIK2

Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). It is acted on by 1 drug in DrugBank.

Gene name
SIK2
UniProtKB entry
Q9H0K1Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
926 residues · 103,914 Da
Also known as
2.7.11.1 · KIAA0781 · QIK · Qin-induced kinase · Salt-inducible kinase 2

Resolves to

Protein
UniProtQ9H0K1UniProt nameSIK2_HUMAN
Gene
HGNCHGNC:21680NCBI Gene23235GeneCardsSIK2
Pharmacology
IUPHAR/GtoPdb2198KEGGhsa:23235
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase SIK2, how selective are they, and which programs against it are still in active trials?

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