Epoxide hydrolase 1

BE0009565ProteinHumansEPHX1

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). It is acted on by 3 drugs in DrugBank.

Gene name
EPHX1
UniProtKB entry
P07099Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
455 residues · 52,948 Da
Also known as
3.3.2.9 · EPHX · EPOX · Epoxide hydratase · mEH

Resolves to

Protein
UniProtP07099UniProt nameHYEP_HUMAN
Gene
HGNCHGNC:3401NCBI Gene2052GeneCardsEPHX1
Pharmacology
KEGGhsa:2052
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epoxide hydrolase 1, how selective are they, and which programs against it are still in active trials?

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