Polyamine deacetylase HDAC10
Details
- Name
- Polyamine deacetylase HDAC10
- Kind
- protein
- Synonyms
- 3.5.1.48
- 3.5.1.62
- HD10
- Histone deacetylase 10
- Gene Name
- HDAC10
- UniProtKB Entry
- Q969S8Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0006798|Polyamine deacetylase HDAC10 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM LQCHPHLVA
- Number of residues
- 669
- Molecular Weight
- 71444.08
- Theoretical pI
- 5.58
- GO Classification
- Functionsacetylputrescine deacetylase activity / acetylspermidine deacetylase activity / deacetylase activity / protein lysine deacetylase activity / zinc ion bindingProcessesDNA repair / epigenetic regulation of gene expression / homologous recombination / macroautophagy / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / polyamine deacetylation / positive regulation of mismatch repair / regulation of DNA-templated transcription / spermidine deacetylationComponentscytosol / intracellular membrane-bounded organelle
- General Function
- Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039)
- Specific Function
- acetylputrescine deacetylase activity
- Pfam Domain Function
- Hist_deacetyl (PF00850)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051551|Histone deacetylase 10 (HDAC10) ATGGGGACCGCGCTTGTGTACCATGAGGACATGACGGCCACCCGGCTGCTCTGGGACGAC CCCGAGTGCGAGATCGAGCGTCCTGAGCGCCTGACCGCAGCCCTGGATCGCCTGCGGCAG CGCGGCCTGGAACAGAGGTGTCTGCGGTTGTCAGCCCGCGAGGCCTCGGAAGAGGAGCTG GGCCTGGTGCACAGCCCAGAGTATGTATCCCTGGTCAGGGAGACCCAGGTCCTAGGCAAG GAGGAGCTGCAGGCGCTGTCCGGACAGTTCGACGCCATCTACTTCCACCCGAGTACCTTT CACTGCGCGCGGCTGGCCGCAGGGGCTGGACTGCAGCTGGTGGACGCTGTGCTCACTGGA GCTGTGCAAAATGGGCTTGCCCTGGTGAGGCCTCCCGGGCACCATGGCCAGAGGGCGGCT GCCAACGGGTTCTGTGTGTTCAACAACGTGGCCATAGCAGCTGCACATGCCAAGCAGAAA CACGGGCTACACAGGATCCTCGTCGTGGACTGGGATGTGCACCATGGCCAGGGGATCCAG TATCTCTTTGAGGATGACCCCAGCGTCCTTTACTTCTCCTGGCACCGCTATGAGCATGGG CGCTTCTGGCCTTTCCTGCGAGAGTCAGATGCAGACGCAGTGGGGCGGGGACAGGGCCTC GGCTTCACTGTCAACCTGCCCTGGAACCAGGTTGGGATGGGAAACGCTGACTACGTGGCT GCCTTCCTGCACCTGCTGCTCCCACTGGCCTTTGAGTTTGACCCTGAGCTGGTGCTGGTC TCGGCAGGATTTGACTCAGCCATCGGGGACCCTGAGGGGCAAATGCAGGCCACGCCAGAG TGCTTCGCCCACCTCACACAGCTGCTGCAGGTGCTGGCCGGCGGCCGGGTCTGTGCCGTG CTGGAGGGCGGCTACCACCTGGAGTCACTGGCGGAGTCAGTGTGCATGACAGTACAGACG CTGCTGGGTGACCCGGCCCCACCCCTGTCAGGGCCAATGGCGCCATGTCAGAGTGCCCTA GAGTCCATCCAGAGTGCCCGTGCTGCCCAGGCCCCGCACTGGAAGAGCCTCCAGCAGCAA GATGTGACCGCTGTGCCGATGAGCCCCAGCAGCCACTCCCCAGAGGGGAGGCCTCCACCT CTGCTGCCTGGGGGTCCAGTGTGTAAGGCAGCTGCATCTGCACCGAGCTCCCTCCTGGAC CAGCCGTGCCTCTGCCCCGCACCCTCTGTCCGCACCGCTGTTGCCCTGACAACGCCGGAT ATCACATTGGTTCTGCCCCCTGACGTCATCCAACAGGAAGCGTCAGCCCTGAGGGAGGAG ACAGAAGCCTGGGCCAGGCCACACGAGTCCCTGGCCCGGGAGGAGGCCCTCACTGCACTT GGGAAGCTCCTGTACCTCTTAGATGGGATGCTGGATGGGCAGGTGAACAGTGGTATAGCA GCCACTCCAGCCTCTGCTGCAGCAGCCACCCTGGATGTGGCTGTTCGGAGAGGCCTGTCC CACGGAGCCCAGAGGCTGCTGTGCGTGGCCCTGGGACAGCTGGACCGGCCTCCAGACCTC GCCCATGACGGGAGGAGTCTGTGGCTGAACATCAGGGGCAAGGAGGCGGCTGCCCTATCC ATGTTCCATGTCTCCACGCCACTGCCAGTGATGACCGGTGGTTTCCTGAGCTGCATCTTG GGCTTGGTGCTGCCCCTGGCCTATGGCTTCCAGCCTGACCTGGTGCTGGTGGCGCTGGGG CCTGGCCATGGCCTGCAGGGCCCCCACGCTGCACTCCTGGCTGCAATGCTTCGGGGGCTG GCAGGGGGCCGAGTCCTGGCCCTCCTGGAGGAGAACTCCACACCCCAGCTAGCAGGGATC CTGGCCCGGGTGCTGAATGGAGAGGCACCTCCTAGCCTAGGCCCTTCCTCTGTGGCCTCC CCAGAGGACGTCCAGGCCCTGATGTACCTGAGAGGGCAGCTGGAGCCTCAGTGGAAGATG TTGCAGTGCCATCCTCACCTGGTGGCTTGA
- Chromosome Location
- 22
- Locus
- 22q13.33
- External Identifiers
Resource Link UniProtKB ID Q969S8 UniProtKB Entry Name HDA10_HUMAN GenBank Gene ID AL512711 GeneCard ID HDAC10 GenAtlas ID HDAC10 HGNC ID HGNC:18128 KEGG ID hsa:83933 IUPHAR/Guide To Pharmacology ID 2614 NCBI Gene ID 83933 - General References
- Tong JJ, Liu J, Bertos NR, Yang XJ: Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 2002 Mar 1;30(5):1114-23. [Article]
- Guardiola AR, Yao TP: Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem. 2002 Feb 1;277(5):3350-6. Epub 2001 Nov 28. [Article]
- Kao HY, Lee CH, Komarov A, Han CC, Evans RM: Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J Biol Chem. 2002 Jan 4;277(1):187-93. Epub 2001 Oct 24. [Article]
- Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D: Isolation and characterization of a novel class II histone deacetylase, HDAC10. J Biol Chem. 2002 Feb 22;277(8):6656-66. Epub 2001 Dec 5. [Article]
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
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- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Bufexamac approved, withdrawn unknown target inhibitor Details 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE experimental yes target inhibitor Details