Polyprenal reductase

BE0009587ProteinHumansSRD5A3

Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (PubMed:20637498, PubMed:38821050). It is acted on by 3 drugs in DrugBank.

Gene name
SRD5A3
UniProtKB entry
Q9H8P0Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
318 residues · 36,521 Da
Also known as
1.3.1.94 · 3-oxo-5-alpha-steroid 4-dehydrogenase 3 · S5AR 3 · SR type 3 · SRD5A2L

Resolves to

Protein
UniProtQ9H8P0UniProt nameSR5A3_HUMAN
Gene
HGNCHGNC:25812NCBI Gene79644GeneCardsSRD5A3
Pharmacology
KEGGhsa:79644
Drugs

What you can answer from here — as of October 08, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polyprenal reductase, how selective are they, and which programs against it are still in active trials?

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