Protein kinase C zeta type

BE0009589ProteinHumansPRKCZ

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of... It is acted on by 2 drugs in DrugBank.

Gene name
PRKCZ
UniProtKB entry
Q05513Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
592 residues · 67,659 Da
Also known as
2.7.11.13 · nPKC-zeta · PKC2

Resolves to

Protein
UniProtQ05513UniProt nameKPCZ_HUMAN
Gene
HGNCHGNC:9412NCBI Gene5590GeneCardsPRKCZ
Pharmacology
IUPHAR/GtoPdb1491KEGGhsa:5590
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein kinase C zeta type, and which indications are they being tested in?

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