Go-6976
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Go-6976
- DrugBank Accession Number
- DB17029
- Background
An inhibitor of calcium-dependent isoforms of protein kinase C.1,2
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 378.435
Monoisotopic: 378.148061216 - Chemical Formula
- C24H18N4O
- Synonyms
- 12h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-
- External IDs
- GO-6976
- GOE-6976
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- B9IQO7JZ16
- CAS number
- 136194-77-9
- InChI Key
- VWVYILCFSYNJHF-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
- IUPAC Name
- 3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaen-3-yl}propanenitrile
- SMILES
- CN1C2=C(C=CC=C2)C2=C1C1=C(C3=C2C(=O)NC3)C2=CC=CC=C2N1CCC#N
References
- General References
- Behrens MM, Strasser U, Choi DW: Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J Neurochem. 1999 Mar;72(3):919-24. doi: 10.1046/j.1471-4159.1999.0720919.x. [Article]
- Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C: Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem. 1993 May 5;268(13):9194-7. [Article]
- External Links
- ChemSpider
- 3381
- BindingDB
- 3033
- ChEBI
- 51913
- ChEMBL
- CHEMBL302449
- ZINC
- ZINC000001554668
- PDBe Ligand
- 85X
- PDB Entries
- 5xgm / 5xgn
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0566 mg/mL ALOGPS logP 4.11 ALOGPS logP 3.25 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 13.53 Chemaxon pKa (Strongest Basic) -1.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 62.75 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 112.97 m3·mol-1 Chemaxon Polarizability 41.87 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at October 11, 2022 17:03 / Updated at December 01, 2022 11:33