Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

BE0009594ProteinHumansITPR2

Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. It is acted on by 2 drugs in DrugBank.

Gene name
ITPR2
UniProtKB entry
Q14571Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
2,701 residues · 308,061 Da
Also known as
Inositol 1,4,5-trisphosphate receptor type 2 · InsP3R2 · IP3 receptor isoform 2 · IP3R 2 · Type 2 inositol 1,4,5-trisphosphate receptor

Resolves to

Protein
UniProtQ14571UniProt nameITPR2_HUMAN
Gene
HGNCHGNC:6181NCBI Gene3709GeneCardsITPR2
Pharmacology
KEGGhsa:3709
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2, how selective are they, and which programs against it are still in active trials?

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