Sclerostin

BE0009665ProteinHumansSOST

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. It is acted on by 8 drugs in DrugBank.

Gene name
SOST
UniProtKB entry
Q9BQB4Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
213 residues · 24,030 Da

Resolves to

Protein
UniProtQ9BQB4UniProt nameSOST_HUMAN
Gene
HGNCHGNC:13771NCBI Gene50964GeneCardsSOST
Pharmacology
KEGGhsa:50964
Structure
PDB2K8PPDB3SOVPDB6L6R
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sclerostin, how selective are they, and which programs against it are still in active trials?

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