Melanocortin receptor 4

BE0009682ProteinHumansMC4R

G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed:25163632, PubMed:32327598, PubMed:33858992, PubMed:8392067). It is acted on by 7 drugs in DrugBank.

Gene name
MC4R
UniProtKB entry
P32245Swiss-Prot
Cellular location
Cell membrane
Residues / weight
332 residues · 36,942 Da
Also known as
MC4-R

Resolves to

Protein
UniProtP32245UniProt nameMC4R_HUMAN
Gene
HGNCHGNC:6932NCBI Gene4160GeneCardsMC4R
Pharmacology
IUPHAR/GtoPdb285KEGGhsa:4160
Structure
PDB6W25PDB7AUEPDB7F53
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Melanocortin receptor 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In