Melanocortin receptor 3

BE0009683ProteinHumansMC3R

G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8463333). It is acted on by 3 drugs in DrugBank.

Gene name
MC3R
UniProtKB entry
P41968Swiss-Prot
Cellular location
Cell membrane
Residues / weight
323 residues · 36,043 Da
Also known as
MC3-R

Resolves to

Protein
UniProtP41968UniProt nameMC3R_HUMAN
Gene
HGNCHGNC:6931NCBI Gene4159GeneCardsMC3R
Pharmacology
IUPHAR/GtoPdb284KEGGhsa:4159
Structure
PDB8IOCPDB8KIGPDB8W8W
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Melanocortin receptor 3, how selective are they, and which programs against it are still in active trials?

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