Polymerase acidic protein

BE0009736ProteinInfluenza A virus (strain A/Puerto Rico/8/1934 H1N1)PA

Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. It is acted on by 3 drugs in DrugBank.

Gene name
PA
UniProtKB entry
P03433Swiss-Prot
Cellular location
Host cytoplasm
Residues / weight
716 residues · 82,588 Da
Also known as
3.1.-.- · RNA-directed RNA polymerase subunit P2

Resolves to

Protein
UniProtP03433UniProt namePA_I34A1
Gene
NCBI Gene956535
Pharmacology
KEGGvg:956535
Structure
PDB2ZNLPDB4YYLPDB4ZHZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polymerase acidic protein, how selective are they, and which programs against it are still in active trials?

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