Pepsin A-5

BE0009737ProteinHumansPGA5

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. It is acted on by 6 drugs in DrugBank.

Gene name
PGA5
UniProtKB entry
P0DJD9Swiss-Prot
Cellular location
Secreted
Residues / weight
388 residues · 41,993 Da
Also known as
3.4.23.1 · Pepsinogen-5

Resolves to

Protein
UniProtP0DJD9UniProt namePEPA5_HUMAN
Gene
HGNCHGNC:8887NCBI Gene5222GeneCardsPGA5
Pharmacology
IUPHAR/GtoPdb2390KEGGhsa:5222
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pepsin A-5, how selective are they, and which programs against it are still in active trials?

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