Transient receptor potential cation channel subfamily M member 4

BE0009748ProteinHumansTRPM4

Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). It is acted on by 2 drugs in DrugBank.

Gene name
TRPM4
UniProtKB entry
Q8TD43Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,214 residues · 134,300 Da
Also known as
Calcium-activated non-selective cation channel 1 · hTRPM4 · Long transient receptor potential channel 4 · LTrpC-4 · LTRPC4

Resolves to

Protein
UniProtQ8TD43UniProt nameTRPM4_HUMAN
Gene
HGNCHGNC:17993NCBI Gene54795GeneCardsTRPM4
Pharmacology
IUPHAR/GtoPdb496KEGGhsa:54795
Structure
PDB5WP6PDB6BQRPDB6BQV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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31GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily M member 4, how selective are they, and which programs against it are still in active trials?

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