Hexokinase-2

BE0009792ProteinHumansHK2

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). It is acted on by 3 drugs in DrugBank.

Gene name
HK2
UniProtKB entry
P52789Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
917 residues · 102,379 Da
Also known as
2.7.1.1 · Hexokinase type II · Hexokinase-B · HK II · Muscle form hexokinase

Resolves to

Protein
UniProtP52789UniProt nameHXK2_HUMAN
Gene
HGNCHGNC:4923NCBI Gene3099GeneCardsHK2
Pharmacology
KEGGhsa:3099
Structure
PDB2NZTPDB5HEXPDB5HFU
Drugs

What you can answer from here — as of December 05, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hexokinase-2, how selective are they, and which programs against it are still in active trials?

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