Histone-lysine N-methyltransferase EZH1

BE0009849ProteinHumansEZH1

Polycomb group (PcG) protein. It is acted on by 2 drugs in DrugBank.

Gene name
EZH1
UniProtKB entry
Q92800Swiss-Prot
Cellular location
Nucleus
Residues / weight
747 residues · 85,270 Da
Also known as
2.1.1.356 · Enhancer of zeste homolog 1 · ENX-2 · KIAA0388

Resolves to

Protein
UniProtQ92800UniProt nameEZH1_HUMAN
Gene
HGNCHGNC:3526NCBI Gene2145GeneCardsEZH1
Pharmacology
IUPHAR/GtoPdb2835KEGGhsa:2145
Structure
PDB7KSOPDB7KSRPDB7KTP
Drugs

What you can answer from here — as of January 29, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone-lysine N-methyltransferase EZH1, how selective are they, and which programs against it are still in active trials?

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