Type I iodothyronine deiodinase

BE0009854ProteinHumansDIO1

Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:32718224, PubMed:18821722). It is acted on by 3 drugs in DrugBank.

Gene name
DIO1
UniProtKB entry
P49895Swiss-Prot
Cellular location
Cell membrane
Residues / weight
249 residues · 28,924 Da
Also known as
1.21.99.3 · 1.21.99.4 · 5DI · DIOI · ITDI1

Resolves to

Protein
UniProtP49895UniProt nameIOD1_HUMAN
Gene
HGNCHGNC:2883NCBI Gene1733GeneCardsDIO1
Pharmacology
KEGGhsa:1733
Drugs

What you can answer from here — as of February 12, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Type I iodothyronine deiodinase, how selective are they, and which programs against it are still in active trials?

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