Type II iodothyronine deiodinase

BE0009855ProteinHumansDIO2

Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722). It is acted on by 2 drugs in DrugBank.

Gene name
DIO2
UniProtKB entry
Q92813Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
273 residues · 30,551 Da
Also known as
1.21.99.4 · 5DII · DIOII · ITDI2 · TXDI2

Resolves to

Protein
UniProtQ92813UniProt nameIOD2_HUMAN
Gene
HGNCHGNC:2884NCBI Gene1734GeneCardsDIO2
Pharmacology
KEGGhsa:1734
Drugs

What you can answer from here — as of February 12, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Type II iodothyronine deiodinase, how selective are they, and which programs against it are still in active trials?

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