Ferroportin

BE0009856ProteinHumansSLC40A1

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). It is acted on by 7 drugs in DrugBank.

Gene name
SLC40A1
UniProtKB entry
Q9NP59Swiss-Prot
Cellular location
Cell membrane
Residues / weight
571 residues · 62,542 Da
Also known as
Ferroportin-1 · FPN · FPN1 · IREG1 · Iron-regulated transporter 1

Resolves to

Protein
UniProtQ9NP59UniProt nameS40A1_HUMAN
Gene
HGNCHGNC:10909NCBI Gene30061GeneCardsSLC40A1
Pharmacology
KEGGhsa:30061
Structure
PDB6W4SPDB6WBVPDB8BZY
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ferroportin, how selective are they, and which programs against it are still in active trials?

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