Plasma membrane ascorbate-dependent reductase CYBRD1

BE0009859ProteinHumansCYBRD1

Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). It is acted on by 2 drugs in DrugBank.

Gene name
CYBRD1
UniProtKB entry
Q53TN4Swiss-Prot
Cellular location
Cell membrane
Residues / weight
286 residues · 31,641 Da
Also known as
7.2.1.3 · Cytochrome b reductase 1 · DCYTB · Duodenal cytochrome b · Ferric-chelate reductase 3

Resolves to

Protein
UniProtQ53TN4UniProt nameCYBR1_HUMAN
Gene
HGNCHGNC:20797NCBI Gene79901GeneCardsCYBRD1
Pharmacology
KEGGhsa:79901
Structure
PDB5ZLEPDB5ZLG
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Plasma membrane ascorbate-dependent reductase CYBRD1, how selective are they, and which programs against it are still in active trials?

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