Claudin-16

BE0009861ProteinHumansCLDN16

Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). It is acted on by 1 drug in DrugBank.

Gene name
CLDN16
UniProtKB entry
Q9Y5I7Swiss-Prot
Cellular location
Cell junction, tight junction
Residues / weight
235 residues · 26,077 Da
Also known as
Paracellin-1 · PCLN-1 · PCLN1

Resolves to

Protein
UniProtQ9Y5I7UniProt nameCLD16_HUMAN
Gene
HGNCHGNC:2037NCBI Gene10686GeneCardsCLDN16
Pharmacology
KEGGhsa:10686
Drugs

What you can answer from here — as of March 02, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Claudin-16, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In