Claudin-16

Details

Name
Claudin-16
Kind
protein
Synonyms
  • Paracellin-1
  • PCLN-1
  • PCLN1
Gene Name
CLDN16
UniProtKB Entry
Q9Y5I7Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0064386|Claudin-16
MRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRT
CDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRICFVA
GATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAG
AVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYAVDTRV
Number of residues
235
Molecular Weight
26077.22
Theoretical pI
Not Available
GO Classification
Processes
bicellular tight junction assembly / cell adhesion / intercellular transport / intracellular monoatomic cation homeostasis / metal ion transport
General Function
Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:10390358, PubMed:11518780, PubMed:14628289, PubMed:16528408, PubMed:28028216)
Specific Function
Identical protein binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
4-24 80-100 116-136 170-190
Cellular Location
Cell junction, tight junction
Gene sequence
>lcl|BSEQ0052293|Claudin-16 (CLDN16)
ATGACCTCCAGGACCCCACTGTTGGTTACAGCCTGTTTGTATTATTCTTACTGCAACTCA
AGACACCTGCAGCAGGGCGTGAGAAAAAGTAAAAGACCAGTATTTTCACATTGCCAGGTA
CCAGAAACACAGAAGACTGACACCCGCCACTTAAGTGGGGCCAGGGCTGGTGTCTGCCCA
TGTTGCCATCCTGATGGGCTGCTTGCCACAATGAGGGATCTTCTTCAATACATCGCTTGC
TTCTTTGCCTTTTTCTCTGCTGGGTTTTTGATTGTGGCCACCTGGACTGACTGTTGGATG
GTGAATGCTGATGACTCTCTGGAGGTGAGCACAAAATGCCGAGGCCTCTGGTGGGAATGC
GTCACAAATGCTTTTGATGGGATTCGCACCTGTGATGAGTACGATTCCATACTTGCGGAG
CATCCCTTGAAGCTGGTGGTAACTCGAGCGTTGATGATTACTGCAGATATTCTAGCTGGG
TTTGGATTTCTCACCCTGCTCCTTGGTCTTGACTGCGTGAAATTCCTCCCTGATGAGCCG
TACATTAAAGTCCGCATCTGCTTTGTTGCTGGAGCCACGTTACTAATAGCAGGTACCCCA
GGAATCATTGGCTCTGTGTGGTATGCTGTTGATGTGTATGTGGAACGTTCTACTTTGGTT
TTGCACAATATATTTCTTGGTATCCAATATAAATTTGGTTGGTCCTGTTGGCTCGGAATG
GCTGGGTCTCTGGGTTGCTTTTTGGCTGGAGCTGTTCTCACCTGCTGCTTATATCTTTTT
AAAGATGTTGGACCTGAGAGAAACTATCCTTATTCCTTGAGGAAAGCCTATTCAGCCGCG
GGTGTTTCCATGGCCAAGTCATACTCAGCCCCTCGCACAGAGACGGCCAAAATGTATGCT
GTAGACACAAGGGTGTAA
Chromosome Location
3
Locus
3q28
External Identifiers
ResourceLink
UniProtKB IDQ9Y5I7
UniProtKB Entry NameCLD16_HUMAN
GeneCard IDCLDN16
HGNC IDHGNC:2037
KEGG IDhsa:10686
NCBI Gene ID10686
General References
  1. Simon DB, Lu Y, Choate KA, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton RP: Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 1999 Jul 2;285(5424):103-6. doi: 10.1126/science.285.5424.103. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Weber S, Hoffmann K, Jeck N, Saar K, Boeswald M, Kuwertz-Broeking E, Meij II, Knoers NV, Cochat P, Sulakova T, Bonzel KE, Soergel M, Manz F, Schaerer K, Seyberth HW, Reis A, Konrad M: Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. Eur J Hum Genet. 2000 Jun;8(6):414-22. doi: 10.1038/sj.ejhg.5200475. [Article]
  4. Weber S, Schneider L, Peters M, Misselwitz J, Ronnefarth G, Boswald M, Bonzel KE, Seeman T, Sulakova T, Kuwertz-Broking E, Gregoric A, Palcoux JB, Tasic V, Manz F, Scharer K, Seyberth HW, Konrad M: Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2001 Sep;12(9):1872-81. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Magnesiumapproved, experimental, investigationalunknowntransporterDetails