Magnesium transporter MRS2 homolog, mitochondrial

BE0009864ProteinHumansMRS2

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism (PubMed:11401429, PubMed:18384665, PubMed:37543649, PubMed:37938562, PubMed:39609651). It is acted on by 1 drug in DrugBank.

Gene name
MRS2
UniProtKB entry
Q9HD23Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
443 residues · 50,317 Da
Also known as
HPT · MRS2-like protein · MRS2L

Resolves to

Protein
UniProtQ9HD23UniProt nameMRS2_HUMAN
Gene
HGNCHGNC:13785NCBI Gene57380GeneCardsMRS2
Pharmacology
KEGGhsa:57380
Structure
PDB8IP3PDB8IP4PDB8IP5
Drugs

What you can answer from here — as of March 02, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Magnesium transporter MRS2 homolog, mitochondrial, how selective are they, and which programs against it are still in active trials?

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