ATP-citrate synthase

BE0009867ProteinHumansACLY

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. It is acted on by 3 drugs in DrugBank.

Gene name
ACLY
UniProtKB entry
P53396Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,101 residues · 120,838 Da
Also known as
2.3.3.8 · ACL · ATP-citrate (pro-S-)-lyase · Citrate cleavage enzyme

Resolves to

Protein
UniProtP53396UniProt nameACLY_HUMAN
Gene
HGNCHGNC:115NCBI Gene47GeneCardsACLY
Pharmacology
IUPHAR/GtoPdb3245KEGGhsa:47
Structure
PDB3MWDPDB3MWEPDB3PFF
Drugs

What you can answer from here — as of March 11, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-citrate synthase, how selective are they, and which programs against it are still in active trials?

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