Nucleoside diphosphate phosphatase ENTPD5

BE0009876ProteinHumansENTPD5

Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). It is acted on by 1 drug in DrugBank.

Gene name
ENTPD5
UniProtKB entry
O75356Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
428 residues · 47,517 Da
Also known as
3.6.1.6 · CD39 antigen-like 4 · CD39L4 · Ectonucleoside triphosphate diphosphohydrolase 5 · ER-UDPase

Resolves to

Protein
UniProtO75356UniProt nameENTP5_HUMAN
Gene
HGNCHGNC:3367NCBI Gene957GeneCardsENTPD5
Pharmacology
KEGGhsa:957
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleoside diphosphate phosphatase ENTPD5, how selective are they, and which programs against it are still in active trials?

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