Prostaglandin-H2 D-isomerase

BE0009878ProteinHumansPTGDS

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). It is acted on by 2 drugs in DrugBank.

Gene name
PTGDS
UniProtKB entry
P41222Swiss-Prot
Cellular location
Rough endoplasmic reticulum
Residues / weight
190 residues · 21,029 Da
Also known as
5.3.99.2 · Beta-trace protein · Cerebrin-28 · Glutathione-independent PGD synthase · L-PGDS

Resolves to

Protein
UniProtP41222UniProt namePTGDS_HUMAN
Gene
HGNCHGNC:9592NCBI Gene5730GeneCardsPTGDS
Pharmacology
IUPHAR/GtoPdb1380KEGGhsa:5730
Structure
PDB2WWPPDB3O19PDB3O22
Drugs

What you can answer from here — as of March 24, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostaglandin-H2 D-isomerase, how selective are they, and which programs against it are still in active trials?

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