Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced...
- Mechanism
- Curator reviewed
Antrafenine is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
- Primary indication
- Antrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain.Curator reviewed
- Formula / weight
- C30H26F6N4O2 · 588.5435 g/mol (avg)
Resolves to
NWGGKKGAFZIVBJ-UHFFFAOYSA-NSMILESFC(F)(F)C1=CC(=CC=C1)N1CCN(CCOC(=O)C2=CC=CC=C2NC2=C3C=CC(=CC3=NC=C2)C(F)(F)F)CC1What you can answer from here — as of September 13, 2026
Which drugs share a target with Antrafenine, and which of those have an active Phase 3 trial?
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