DNA (cytosine-5)-methyltransferase 3A

BE0009880ProteinHumansDNMT3A

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). It is acted on by 3 drugs in DrugBank.

Gene name
DNMT3A
UniProtKB entry
Q9Y6K1Swiss-Prot
Cellular location
Nucleus
Residues / weight
912 residues · 101,858 Da
Also known as
2.1.1.37 · Cysteine methyltransferase DNMT3A · DNA methyltransferase HsaIIIA · DNA MTase HsaIIIA · Dnmt3a

Resolves to

Protein
UniProtQ9Y6K1UniProt nameDNM3A_HUMAN
Gene
HGNCHGNC:2978NCBI Gene1788GeneCardsDNMT3A
Pharmacology
KEGGhsa:1788
Structure
PDB2QRVPDB3A1APDB3A1B
Drugs

What you can answer from here — as of March 25, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA (cytosine-5)-methyltransferase 3A, how selective are they, and which programs against it are still in active trials?

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