Zinc transporter ZIP10

Details

Name
Zinc transporter ZIP10
Kind
protein
Synonyms
  • KIAA1265
  • Solute carrier family 39 member 10
  • ZIP-10
  • ZIP10
  • Zrt- and Irt-like protein 10
Gene Name
SLC39A10
UniProtKB Entry
Q9ULF5Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052331|Zinc transporter ZIP10
MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEK
KYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEG
KHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRH
HHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKS
NENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPD
NEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLF
TYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLL
SLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHS
HGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEEST
IGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIE
EEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSD
LKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAV
LLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDML
PEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
Number of residues
831
Molecular Weight
94131.47
Theoretical pI
Not Available
GO Classification
Functions
monoatomic cation
Processes
epithelial to mesenchymal transition / intracellular monoatomic cation homeostasis / intracellular zinc ion homeostasis / zinc ion transmembrane transport
Components
apical plasma membrane / plasma membrane
General Function
Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity)
Specific Function
Monoatomic cation
Pfam Domain Function
Signal Regions
1-25
Transmembrane Regions
411-431 438-458 495-515 687-707 732-752 759-779 801-821
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052332|Zinc transporter ZIP10 (SLC39A10)
ATGAAGGTACATATGCACACAAAATTTTGCCTCATTTGTTTGCTGACATTTATTTTTCAT
CATTGCAACCATTGCCATGAAGAACATGACCATGGCCCTGAAGCGCTTCACAGACAGCAT
CGTGGAATGACAGAATTGGAGCCAAGCAAATTTTCAAAGCAAGCTGCTGAAAATGAAAAA
AAATACTATATTGAAAAACTTTTTGAGCGTTATGGTGAAAATGGAAGATTATCCTTTTTT
GGTTTGGAGAAACTTTTAACAAACTTGGGCCTTGGAGAGAGAAAAGTAGTTGAGATTAAT
CATGAGGATCTTGGCCACGATCATGTTTCTCATTTAGATATTTTGGCAGTTCAAGAGGGA
AAGCATTTTCACTCACATAACCACCAGCATTCCCATAATCATTTAAATTCAGAAAATCAA
ACTGTGACCAGTGTATCCACAAAAAGAAACCATAAATGTGATCCAGAGAAAGAGACAGTT
GAAGTGTCTGTAAAATCTGATGATAAACATATGCATGACCATAATCACCGCCTACGTCAT
CACCATCGTTTGCATCATCATCTTGATCATAACAACACTCACCATTTTCATAATGATTCC
ATTACTCCCAGTGAGCGTGGGGAGCCTAGCAATGAACCTTCAACAGAGACCAATAAAACC
CAGGAACAATCTGATGTTAAACTACCGAAAGGAAAGAGGAAGAAAAAAGGGAGGAAAAGT
AATGAAAATTCTGAGGTTATTACACCAGGTTTTCCCCCTAACCATGATCAGGGTGAACAG
TATGAGCATAATCGGGTCCACAAACCTGATCGTGTACATAACCCAGGTCATTCTCATGTA
CATCTTCCAGAACGTAATGGTCATGATCCTGGTCGTGGACACCAAGATCTTGATCCTGAT
AATGAAGGTGAACTTCGACATACTAGAAAGAGAGAAGCACCACATGTTAAAAATAATGCA
ATAATTTCTTTGAGAAAAGATCTAAATGAAGATGACCATCATCATGAATGTTTGAACGTC
ACTCAGTTATTAAAATACTATGGTCATGGTGCCAACTCTCCCATCTCAACTGATTTATTT
ACATACCTTTGCCCTGCATTGTTATATCAAATCGACAGCAGACTTTGTATTGAGCATTTT
GACAAACTTTTAGTTGAAGATATAAATAAGGATAAAAACCTGGTTCCTGAAGATGAGGCA
AATATAGGGGCATCAGCCTGGATTTGTGGTATCATTTCTATCACTGTCATTAGCCTGCTT
TCCTTGCTAGGCGTGATCTTGGTTCCTATCATTAACCAAGGATGCTTCAAATTCCTTCTT
ACATTCCTTGTTGCATTAGCTGTAGGAACAATGAGTGGAGACGCCCTTCTTCATCTACTG
CCCCATTCTCAGGGTGGACATGATCACAGTCACCAACATGCACATGGGCATGGACATTCT
CATGGACATGAATCTAACAAGTTTTTGGAAGAATATGATGCTGTATTGAAAGGACTTGTT
GCTCTAGGAGGCATTTACTTGCTATTTATCATTGAACACTGCATTAGAATGTTTAAGCAC
TACAAACAACAAAGAGGAAAACAGAAATGGTTTATGAAACAGAACACAGAAGAATCAACT
ATTGGAAGAAAGCTTTCAGATCACAAGTTAAACAATACACCAGATTCTGACTGGCTTCAA
CTCAAGCCTCTTGCCGGAACTGATGACTCGGTTGTTTCTGAAGATCGACTTAATGAAACT
GAACTGACAGATTTAGAAGGCCAACAAGAATCCCCTCCTAAAAATTACCTTTGTATAGAA
GAGGAGAAAATCATAGACCATTCTCACAGTGATGGATTACATACCATTCATGAGCATGAT
CTCCATGCTGCTGCACATAACCACCACGGCGAGAACAAAACTGTGCTGAGGAAGCATAAT
CACCAGTGGCACCACAAGCATTCTCATCATTCCCATGGCCCCTGTCATTCTGGATCCGAT
CTGAAAGAAACAGGAATAGCTAATATAGCCTGGATGGTGATCATGGGGGATGGCATCCAC
AACTTCAGTGATGGGCTCGCAATTGGTGCAGCTTTCAGTGCTGGATTGACAGGAGGAATC
AGTACTTCTATAGCCGTCTTCTGTCATGAACTGCCACATGAATTAGGAGATTTTGCAGTT
CTTCTTAAAGCAGGCATGACTGTAAAGCAAGCAATTGTATACAACCTCCTCTCTGCCATG
ATGGCTTACATAGGCATGCTCATAGGCACAGCTGTTGGTCAGTATGCCAATAACATCACA
CTTTGGATCTTTGCAGTCACTGCAGGCATGTTCCTCTATGTAGCCTTGGTGGATATGCTT
CCAGAAATGTTGCATGGTGATGGTGACAATGAAGAACATGGCTTTTGTCCTGTGGGGCAA
TTCATCCTTCAGAATTTAGGATTGCTCTTTGGATTTGCCATTATGCTGGTGATTGCCCTC
TATGAAGATAAAATTGTGTTTGACATCCAGTTTTGA
Chromosome Location
2
Locus
2q32.3
External Identifiers
ResourceLink
UniProtKB IDQ9ULF5
UniProtKB Entry NameS39AA_HUMAN
GeneCard IDSLC39A10
HGNC IDHGNC:20861
KEGG IDhsa:57181
NCBI Gene ID57181
General References
  1. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Oct 29;6(5):337-45. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  4. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Kagara N, Tanaka N, Noguchi S, Hirano T: Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci. 2007 May;98(5):692-7. doi: 10.1111/j.1349-7006.2007.00446.x. Epub 2007 Mar 14. [Article]
  7. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Zinc chlorideapproved, investigationalunknowntransportersubstrateDetails
Zinc sulfate, unspecified formapproved, experimentalunknowntransportersubstrateDetails